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In humans, theres no published answer, because no human efficacy trial exists yet

Although its not required in substantial amounts, vitamin B12 plays several big roles (3): Energy production Red blood cell formation (hematopoiesis) DNA synthesis Brain development Nervous system function Fatty acid synthesis Myelin formation Cardiovascular health But the thing with vitamin B12 is that although a deficiency takes a significant amount of time to develop, certain groups are more susceptible to a deficiency than others

they can explain why the benefits for your particular case outweigh any risks

A talk someone posted recently by a doctor mentions that he treats patients with methylfolate and not folic acid